SHBG Antibody

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Immunohistochemistry-Paraffin: SHBG Antibody [NBP1-52408] - Analysis of anti-SHBG antibody with human placenta at concentration 3.75 ug/ml.

Product Details

Summary
Reactivity Hu, Mk, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SHBG Antibody Summary

Immunogen
Synthetic peptide HSCPQSPGNGTDAS from the C-terminus of human SHBG (NP_001031.2).
Specificity
Human SHBG.
Predicted Species
Primate (93%), Monkey (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SHBG
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3.75 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Gorilla (93%), Marmoset (93%), Elephant (86%), Rabbit (86%).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
TBS (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SHBG Antibody

  • ABP
  • ABPTestosterone-estrogen-binding globulin
  • androgen binding protein
  • MGC126834
  • MGC138391
  • SBP
  • sex hormone-binding globulin
  • Sex steroid-binding protein
  • SHBG
  • TEBG
  • Testis-specific androgen-binding protein
  • testosterone-binding beta-globulin
  • Testosterone-estradiol-binding globulin

Background

The gene encodes an EF hand-containing small calcium binding protein. It is an integral subunit component of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Kv4 potassium channels regulate action potentials in neurons and cardiac myocytes. The coexpression of ABP with pore-forming Kv4 alpha subunits causes changes in the gating and amplitude of Kv4 currents, thus profoundly affect the intracellular trafficking and molecular properties of Kv4.2 alpha subunits. It also cause a dramatic redistribution of Kv4.2, releasing intrinsic endoplasmic reticulum retention and allowing for trafficking to the cell surface. It may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. It maps to 5q35.1 region of human chromosome. Alternative splicing results in multiple transcript variant encoding different isoforms. Isoform 1 and isoform 2 are expressed in brain and kidney.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SHBG
Entrez
Uniprot