SH2B2 Antibody

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Product Details

Summary
Product Discontinued
View other related SH2B2 Primary Antibodies

Order Details


    • Catalog Number
      NB100-66034
    • Availability
      Product Discontinued

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SH2B2 Antibody Summary

Immunogen
Peptide with the sequence GRARAVENQYSFY from the C terminus of the protein. Sequence according to the Entrez Gene accession number NP_066189
Specificity
APS, also known as Adapter protein containing pleckstrin homology and src homology 2 domains is an adapter molecule thought to be involved in signal transduction from receptors to Shc/Grb2.
Clonality
Polyclonal
Host
Goat
Gene
SH2B2
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
TBS and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
IgG purified

Alternate Names for SH2B2 Antibody

  • adaptor protein with pleckstrin homology and src homology 2 domains
  • APSAdapter protein with pleckstrin homology and Src homology 2 domains
  • SH2 and PH domain-containing adapter protein APS
  • SH2B adapter protein 2
  • SH2B adaptor protein 2

Background

APS (adapter protein with Pleckstrin homology and Src homology 2 domains) is a member of the Lnk family, an adapter protein that is involved in B cell signaling, insulin signaling and cytoskeletal reorganization. A PH and an SH2 domain containing adapter protein that links activated tyrosine kinases to signaling pathways. It is tyrosine phosphorylated by JAK2, KIT and other kinases during B cell receptor stimulation of many different cytokines, chemokines and leukokines. APS has been shown to inhibit the JAK STAT pathway in collaboration with cCbl.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional SH2B2 Products

SH2B2 NB100-66034

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Bioinformatics

Gene Symbol SH2B2
Entrez
Uniprot