Western Blot: SGK1 Antibody [NBP2-19010] - analysis of SGK1 in human lung lysate in the 1) absence and 2) presence of immunizing peptide, 3) human kidney lysate probed with 1 ug/ml of SGK1 antibody. I goat anti-rabbit ...read more
Immunohistochemistry-Paraffin: SGK1 Antibody [NBP2-19010] - analysis of SGK1 in human lung probed with SGK1 antibody at 5 ug/ml.
WB, IHC, IHC-P
Please see the vial label for concentration. If unlisted please contact technical services.
The amino acid sequence used as immunogen for this antibody is 100% homologous in human, new world monkey, macaque, rhesus monkey, opossum, gibbon, orangutan, and chimpanzee, 95% in panda, carolina anole, cow, dog, chinese hamster, zebrafish, horse, mole rat, elephant, platypus, and pig, 90% in mouse, rat, zebra finch, frog, cichlid fish, rabbit, guinea pig, chicken, and wild turkey, 85% homologouus in salmon.
Alternate Names for SGK Antibody
serine/threonine protein kinase SGK
serine/threonine-protein kinase Sgk1
serum/glucocorticoid regulated kinase 1
serum/glucocorticoid regulated kinase
Serum/glucocorticoid-regulated kinase 1
SGK1, an acronym for serum and glucocorticoid regulated kinase, appears to be important for intrauterine embryo implantation and pregnancy maintenance along with a variety of other pathways such as neuronal excitation, renal sodium ion secretion, apoptosis and T-cell signaling (1, 2). SGK1 activity and stability appears to have an inverse correlation with ubiquitinylation pathways (1, 2). SGK1 has an interaction with Notch through Fbw as the absence of SGK1 promotes Notch protein stability and transcriptional activity. SGK1 association with Tcell signaling is also indicated as Notch and Fbw7 mutations are found in a majority of T-ALL cases (3). Antibody to SGK1 can be useful for further analysis of the relative importance of this kinase in numerous diverse cell processes.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.