Serum Amyloid A1 Antibody (Reu-86.2)

Images

 

Product Details

Summary
Product Discontinued
View other related Serum Amyloid A1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-50111
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

Serum Amyloid A1 Antibody (Reu-86.2) Summary

Immunogen
The antibody reacts with AA-type Amyloid depositions.
Localization
extracellular matrix
Specificity
The antibody reacts with AA-type Amyloid depositions. Amyloidosis includes a family of diseases which have in common the extracellular deposition ofB-pleated fibrillar protein. Amyloidosis associated with chronic inflammat­ory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type. Antigen origin: human serum Amyloid A (Apo-SAA). Antigen location: extracellular matrix.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
SAA1
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
This antibody is very useful in immunohistochemistry on frozen and paraffin sectionsFrozen sections should be fixed with acetone for 5 min. at -20°C. Paraffin sections should be fixed with formaldehyde, no pretreatment is needed. Working dilution: 1: 10, optimal dilution should be tested by serial dilution. Positive control: Amyloid depositions (renal biopsy).

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
I ml tissue culture supernatant
Preservative
0.1% Sodium Azide
Purity
Tissue culture supernatant

Alternate Names for Serum Amyloid A1 Antibody (Reu-86.2)

  • MGC111216
  • PIG4
  • SAA
  • SAA1
  • SAA2
  • serum amyloid A protein
  • Serum Amyloid A1
  • TP53I4
  • tumor protein p53 inducible protein 4

Background

The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis. Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils, which are derived from different proteins. Almost all patients with amyloidosis have some level of renal disorders. The immunoperoxidase technique has the advantage of being able to detect amyloid in formalin-fixed paraffin embedded tissues and is a very specific method for identifying amyloid fibril proteins. Small and minute amounts of amyloid can be detected with both Amyloid P (ab688) and Amyloid A antibodies, and thus could allow earlier treatment before organ damage has occurred.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-43581
Species: Hu
Applications: WB, ICC/IF, IP
AF3856
Species: Hu
Applications: WB, IHC
NBP2-52979
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-17262
Species: Hu
Applications: WB, ICC/IF
AF5739
Species: Hu, Mu, Rt
Applications: WB
NB600-41532
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP2-29323
Species: Hu, Mu, Rt, Bv, Ca, Ch, Xp
NB100-128
Species: Hu, Mu, Rt
Applications: ChIP, GS, ICC/IF, IHC, IHC-P
NBP2-22471
Species: Hu, Mu, Rt, Mk, Pm
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP
AF4409
Species: Mu
Applications: WB
NBP2-61118
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
NB110-60531
Species: Hu, Mu, Rt(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, IP, CyTOF-ready

Publications for Serum Amyloid A1 Antibody (NBP1-50111) (0)

There are no publications for Serum Amyloid A1 Antibody (NBP1-50111).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Serum Amyloid A1 Antibody (NBP1-50111) (0)

There are no reviews for Serum Amyloid A1 Antibody (NBP1-50111). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Serum Amyloid A1 Antibody (NBP1-50111) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Serum Amyloid A1 Products

Bioinformatics Tool for Serum Amyloid A1 Antibody (NBP1-50111)

Discover related pathways, diseases and genes to Serum Amyloid A1 Antibody (NBP1-50111). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Serum Amyloid A1 Antibody (NBP1-50111)

Discover more about diseases related to Serum Amyloid A1 Antibody (NBP1-50111).
 

Pathways for Serum Amyloid A1 Antibody (NBP1-50111)

View related products by pathway.

PTMs for Serum Amyloid A1 Antibody (NBP1-50111)

Learn more about PTMs related to Serum Amyloid A1 Antibody (NBP1-50111).
 

Research Areas for Serum Amyloid A1 Antibody (NBP1-50111)

Find related products by research area.

Blogs on Serum Amyloid A1

There are no specific blogs for Serum Amyloid A1, but you can read our latest blog posts.

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Serum Amyloid A1 Antibody (Reu-86.2) and receive a gift card or discount.

Bioinformatics

Gene Symbol SAA1
Entrez