Serum Amyloid A1 Antibody (Reu-86.2)



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Serum Amyloid A1 Antibody (Reu-86.2) Summary

The antibody reacts with AA-type Amyloid depositions.
extracellular matrix
The antibody reacts with AA-type Amyloid depositions. Amyloidosis includes a family of diseases which have in common the extracellular deposition ofB-pleated fibrillar protein. Amyloidosis associated with chronic inflammat­ory conditions (AA-type) and Amyloidosis related to plasma cel dyscrasia (AL-type) are the most common, but the frequency of amyloidosis associated with chronic haemodialysis (B2M-type) is growing rapidly. Reu-86.2 can be used in routine diagnosis of amyloidosis both for detection of the AA-type as for the discimination from the other types of amyloidosis such as the B2M- and AL-type. Antigen origin: human serum Amyloid A (Apo-SAA). Antigen location: extracellular matrix.
Tissue culture supernatant
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
1 ml. tissue culture supernatant with 0.1% sodium azide.
0.1% Sodium Azide
This product is unpurified. The exact concentration of antibody is not quantifiable.
Tissue culture supernatant


Application Notes
This antibody is very useful in immunohistochemistry on frozen and paraffin sectionsFrozen sections should be fixed with acetone for 5 min. at -20°C. Paraffin sections should be fixed with formaldehyde, no pretreatment is needed. Working dilution: 1: 10, optimal dilution should be tested by serial dilution. Positive control: Amyloid depositions (renal biopsy).

Reactivity Notes



The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis. Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils, which are derived from different proteins. Almost all patients with amyloidosis have some level of renal disorders. The immunoperoxidase technique has the advantage of being able to detect amyloid in formalin-fixed paraffin embedded tissues and is a very specific method for identifying amyloid fibril proteins. Small and minute amounts of amyloid can be detected with both Amyloid P (ab688) and Amyloid A antibodies, and thus could allow earlier treatment before organ damage has occurred.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol SAA1

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