Securin Antibody (4E5)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      H00009232-M65
    • Availability
      Product Discontinued

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Securin Antibody (4E5) Summary

Immunogen
PTTG1 (NP_004210, 0 a.a. ~ 0 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
PTTG1 - pituitary tumor-transforming 1 (4E5)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PTTG1
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • ELISA
Application Notes
This antibody is useful for ELISA.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Securin Antibody (4E5)

  • EAP1MGC126883
  • ESP1-associated protein 1
  • Esp1-associated protein
  • hPTTG
  • pituitary tumor-transforming 1
  • Pituitary tumor-transforming gene 1 protein
  • PTTGMGC138276
  • securin
  • Tumor-transforming protein 1
  • TUTR1HPTTG

Background

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PTTG1
Entrez
Uniprot