SCN2A Antibody

Product Discontinued

SCN2A Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 1002-1052 of Human Na+ CP type IIalpha.
• Specificity: Na+ CP type IIalpha (K1032) detects endogenous levels of Na+ CP type IIalpha protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SCN2A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
• Application Notes: Immunohistochemistry (IHC) analyzes of Na+ CP type IIalpha (K1032) pAb in paraffin-embedded human brain tissue.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for SCN2A Antibody

• BFIC3
• brain type 2 alpha subunit
• EIEE11
• HBA
• HBSC II
• HBSCI
• HBSCII
• Na(v)1.2
• NAC2
• Nav1.2
• SCN2A
• SCN2A1
• SCN2A1HBSC II
• SCN2A2
• sodium channel, voltage-gated, type II, alpha 1 polypeptide
• sodium channel, voltage-gated, type II, alpha 2 polypeptide
• sodium channel, voltage-gated, type II, alpha subunit
• voltage-gated sodium channel subtype II
• Voltage-gated sodium channel subunit alpha Nav1.2

Background

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfide-linked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIalpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SCN2A
• Entrez:
  • 6326(Human)
  • 110876(Mouse)
  • 24766(Rat)