SCN2A Antibody (S69-3)

Product Discontinued

SCN2A Antibody (S69-3) Summary

• Immunogen: Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat Nav1.2
• Localization: Membrane
• Specificity: The product is specific for ~250kDa. Lack of cross reactivity against Nav1.1, Nav1.3, Nav1.6 verified.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SCN2A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 0.1-1.0 ug/ml
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1 ug/ml

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4) and 50% Glycerol
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for SCN2A Antibody (S69-3)

• BFIC3
• brain type 2 alpha subunit
• EIEE11
• HBA
• HBSC II
• HBSCI
• HBSCII
• Na(v)1.2
• NAC2
• Nav1.2
• SCN2A
• SCN2A1
• SCN2A1HBSC II
• SCN2A2
• sodium channel, voltage-gated, type II, alpha 1 polypeptide
• sodium channel, voltage-gated, type II, alpha 2 polypeptide
• sodium channel, voltage-gated, type II, alpha subunit
• voltage-gated sodium channel subtype II
• Voltage-gated sodium channel subunit alpha Nav1.2

Background

SCN2A is a member of the sodium channel alpha subunit family and mediates the voltage-dependent sodium ion permeability of excitable membranes. It assumes an opened or closed conformations in response to the voltage difference across the membrane and forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SCN2A Antibody (NBP1-48248)(1)

Publication using NBP1-48248

• Flowerdew SE, Burgoyne RD. A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels. Biochem J;418(3):529-40. 2009-03-15 [PMID: 19138172]

Bioinformatics

• Gene Symbol: SCN2A
• Entrez:
  • 24766(Rat)
• Uniprot:
  • P04775(Rat)