Scn1a Antibody (S74-71)

Images

 
Immunohistochemistry: Scn1a Antibody (S74-71) [NBP1-49615] - Normal brain, neuronal cells, cytoplasmic staining. Image from verified customer review.
Immunohistochemistry-Frozen: Scn1a Antibody (S74-71) [NBP1-49615] - frozen sections of mouse brain extract using this antibody.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-49615
    • Availability
      Product Discontinued

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Scn1a Antibody (S74-71) Summary

Immunogen
Fusion protein amino acids 1929-2009 (cytoplamsic Cterminus) of rat Nav1.1, accession number P04774 (NP_061203.2).
Specificity
~220kDa. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
SCN1A
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 0.1-1.0 ug/ml
  • Immunoprecipitation 1:10-1:500
Reviewed Applications
Read 1 Review rated 4
using
NBP1-49615 in the following applications:

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 50% Glycerol
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for Scn1a Antibody (S74-71)

  • brain I alpha subunit
  • EIEE6
  • FEB3
  • GEFSP2FHM3
  • HBSCI
  • NAC1FEB3A
  • Nav1.1
  • SCN1
  • SMEIfebrile convulsions 3
  • sodium channel, voltage-gated, type I, alpha polypeptide
  • sodium channel, voltage-gated, type I, alpha subunit

Background

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Review for Scn1a Antibody (NBP1-49615) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: IHC.

Reviews using NBP1-49615:
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Images Ratings Applications Species Date Details
Immunohistochemistry Scn1a NBP1-49615
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reviewed by:
Anony- mous
IHC Human 04/21/2014
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Summary

ApplicationImmunohistochemistry
SpeciesHuman
FileView PDF

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Anony- mous
04/21/2014
Application: IHC
Species: Human

Bioinformatics

Gene Symbol SCN1A
Entrez
Uniprot