Scaffold attachment factor B2 Antibody

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Western Blot: Scaffold attachment factor B2 Antibody [NB100-58792] - Detection of Human SAFB2 on HeLa whole cell lysate using NB100-58792. SAFB2 was also immunoprecipitated by rabbit anti-SAFB2 antibodies NB100-58791 ...read more

Order Details


    • Catalog Number
      NB100-58792
    • Availability
      Product Discontinued

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Scaffold attachment factor B2 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 375 and 425 of human scaffold attachment factor B2 using the numbering given in entry NP_055464.1 (GeneID 9667).
Clonality
Polyclonal
Host
Rabbit
Gene
SAFB2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Scaffold attachment factor B2 Antibody

  • KIAA0138SAF-B2
  • scaffold attachment factor B2

Background

Activity of the estrogen receptor (ER) is regulated through interaction with coactivators and corepressors. These proteins are present in large complexes, suggesting functional interactions among various cofactors. The scaffold attachment factor SAFB2, a component of high molecular weight nuclear protein complexes which contains a core set of protein interaction partners, functions as an estrogen receptor corepressor. It directly interacts with ER alpha repressing transcription via repression domains. Its over expression results in inhibition of proliferation. SAFB2 is found in the cytoplasm, as well as the nucleus. Consistent with its cytoplasmic localization, there is also an interaction between SAFB2 and vinexin, a protein involved in linking signaling to the cytoskeleton.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SAFB2
Uniprot