S1P2/EDG-5/S1PR2 Antibody

Images

 
Western Blot: S1P2/EDG-5/S1PR2 Antibody [NBP1-00794] - Analysis of EDG-5 (L303) pAb at 1:1000 dilutionLane1:Hela whole cell lysate( 20ug) Lane2:pc12 whole cell lysate(20ug)
Immunohistochemistry-Paraffin: S1P2/EDG-5/S1PR2 Antibody [NBP1-00794] - Paraffin-embedded human colon carcinoma tissue at 1:50.showing cytoplasmic and membrane staining.
Western Blot: S1PR2 Antibody [NBP1-00794] - Western blot (WB) analysis of EDG-5 (L303) antibody in extracts from COLO205 cells.
Western Blot: S1PR2 Antibody [NBP1-00794] Extracts from PC12 cells.
Western Blot: S1PR2 Antibody [NBP1-00794] - Lane1:Hela cell lysate. Lane2:PC12 cell lysate.

Product Details

Summary
Product Discontinued
View other related S1P2/EDG-5/S1PR2 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-00794
    • Availability
      Product Discontinued

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S1P2/EDG-5/S1PR2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 281-330 of Human EDG-5.
Specificity
EDG-5 (L303) detects endogenous levels of EDG-5 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
S1PR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500- 1:1000
  • Immunocytochemistry/Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Theoretical MW
39 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NBP1-00794.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for S1P2/EDG-5/S1PR2 Antibody

  • AGR16
  • EDG5
  • EDG-5
  • endothelial differentiation G-protein coupled receptor 5
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
  • GPCR13
  • GPCR18
  • H218
  • LPB2
  • S1P receptor 2
  • S1P receptor EDG5
  • S1P receptor Edg-5
  • S1P2
  • S1PR2
  • sphingosine 1-phosphate receptor 2
  • sphingosine 1-phosphate receptor Edg-5
  • sphingosine-1-phosphate receptor 2

Background

The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain. EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for S1P2/EDG-5/S1PR2 Antibody (NBP1-00794)(1)

We have publications tested in 1 application: WB.


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Bioinformatics

Gene Symbol S1PR2
Entrez