RXR alpha/NR2B1 [p Ser61] Antibody

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Immunohistochemistry-Paraffin: RXR alpha/NR2B1 [p Ser61] Antibody [NB100-78537] - Formalin-fixed paraffin-embedded human tonsil tissue was stained with Poly6329 and developed with an alkaline phosphatase chromogen ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-78537
    • Availability
      Product Discontinued

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RXR alpha/NR2B1 [p Ser61] Antibody Summary

Immunogen
Modified peptide
Modification
p Ser61
Specificity
RXR alpha [Ser61]
Clonality
Polyclonal
Host
Rabbit
Gene
RXRA
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
Application Notes
Each lot of this antibody is quality control tested by Immunofluorescence staining. For immunofluorescence microscopy, suggested working dilution(s): Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimal performance for each application.

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RXR alpha/NR2B1 [p Ser61] Antibody

  • FLJ00280
  • FLJ00318
  • FLJ16020
  • MGC102720
  • NR2B1
  • NR2B1FLJ16733
  • Nuclear receptor subfamily 2 group B member 1
  • retinoic acid receptor RXR-alpha
  • Retinoid X receptor alpha
  • retinoid X receptor, alpha
  • RXR alpha
  • RXRA

Background

RXR alpha (Retinoic acid receptor RXR alpha) is a 51KD member of the nuclear hormone receptor family, NR2 subfamily. This nuclear protein contains three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. The expression of RXR alpha is modulated differently during the activation of cell cycling. There are three retinoic acid receptors (RXR), RXR alpha, RXR, and RXR gamma encoded by the RXRA, RXRB, RXRG genes respectively. RXRs play an important role as promiscuous heterodimerization partners in modulating the activities of a number of nuclear receptors, which include RAR, thyroid hormone receptor, vitamin D receptor, peroxisome proliferator activated receptors, and COUP-TF. The poly6329 antibody recognizes human phosphorylated RXR alpha(Ser61) and has been shown to be useful for immunoflorence staining.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

FAQs for RXR alpha/NR2B1 Antibody (NB100-78537). (Showing 1 - 2 of 2 FAQ).

  1. Can this antibody also be used for detection of chick RXR alpha (pSer61)?
    • We have not performed in house testing on chicken cells, but UniProt shows a high level of homology between human and chicken Retinoid X Receptor alpha, so there is a chance it can cross-react.
  2. Is the phosphorylation of Ser61 of the Retinoid X Receptor alpha an indication of its transciptional active state?
    • It would seem that phosphorylation of Ser61 of Retinoid X Receptor alpha is indicative of an active transcription state, as seen in the reference below: "Recently, it has been found that three additional residues (Ser61, Ser75 and Thr87) located in the same N-terminal domain can be also phosphorylated in response to retinoids (Gianni et al., 2003) and that this phosphorylation modulates the synergy between both heterodimeric partners for maximal transcriptional activity, very likely through helping the recruitment of coregulators." Here is a link to that reference.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol RXRA
Entrez