RP105/CD180 Antibody (RP/14)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB120-11857
    • Availability
      Product Discontinued

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RP105/CD180 Antibody (RP/14) Summary

Immunogen
Unfortunately, this information is considered to be commercially sensitive
Localization
Plasma membrane
Specificity
RP105 (RP/14)
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
CD180
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
Flow Cytometry Use at a dilution of 1/10. For use in biological assays, antibody should be filter sterilised and dialysed to remove azide.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Mouse.Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for RP105/CD180 Antibody (RP/14)

  • CD180 antigenMGC126233
  • CD180 molecule
  • CD180
  • Ly64
  • LY64MGC126234
  • Ly78
  • Lymphocyte antigen 64
  • lymphocyte antigen-64, radioprotective, 105kDa
  • Radioprotective 105 kDa protein
  • RP105
  • RP105lymphocyte antigen 64 (mouse) homolog, radioprotective, 105kD

Background

RP105 is a type I transmembrane protein of 105 KDa with extracellular leucine rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to drosophila Toll in the extracellular LLRs. RP105 is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody mediated (RP/14) cross-linking of RP105 induces resistance against irradiation induced apoptosis, B cell proliferation and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B cell activation. RP105 has an important role in B cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B cell surface expression and LPS recognition and signalling. MD1 seems to be requisite for efficient expression of RP105.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD180
Entrez