RP105/CD180 Antibody (RP/14)



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RP105/CD180 Antibody (RP/14) Summary

Unfortunately, this information is considered to be commercially sensitive
Plasma membrane
RP105 (RP/14)
Protein A or G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.1% BSA, PBS
0.02% Sodium Azide
0.1 mg/ml
Protein A or G purified


Application Notes
Flow Cytometry Use at a dilution of 1/10. For use in biological assays, antibody should be filter sterilised and dialysed to remove azide.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Mouse.Not yet tested in other species.


RP105 is a type I transmembrane protein of 105 KDa with extracellular leucine rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to drosophila Toll in the extracellular LLRs. RP105 is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody mediated (RP/14) cross-linking of RP105 induces resistance against irradiation induced apoptosis, B cell proliferation and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B cell activation. RP105 has an important role in B cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B cell surface expression and LPS recognition and signalling. MD1 seems to be requisite for efficient expression of RP105.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol CD180

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