RIPK3/RIP3 Antibody

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Immunohistochemistry-Paraffin: RIPK3/RIP3 Antibody [NBP1-39723] - Staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-39723
    • Availability
      Product Discontinued

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RIPK3/RIP3 Antibody Summary

Immunogen
A portion of amino acids 480-530 of human RIP3
Specificity
A portion of amino acids 480-530 of human RIP3
Clonality
Polyclonal
Host
Rabbit
Gene
RIPK3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 10 ug/ml

Reactivity Notes

Human, Chimpanzee

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS, 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RIPK3/RIP3 Antibody

  • EC 2.7.11.1
  • Receptor-interacting protein 3
  • receptor-interacting serine/threonine-protein kinase 3
  • receptor-interacting serine-threonine kinase 3
  • RIP3
  • RIP-3
  • RIP3receptor interacting protein 3
  • RIPK3
  • RIP-like protein kinase 3

Background

Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 (1-3). RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kappaB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues (2,3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for RIPK3/RIP3 Antibody (NBP1-39723)

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Diseases for RIPK3/RIP3 Antibody (NBP1-39723)

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PTMs for RIPK3/RIP3 Antibody (NBP1-39723)

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Bioinformatics

Gene Symbol RIPK3
Entrez
Uniprot