Renal Cell Carcinoma (gp200) Antibody (66.4.C2 (PN-15)) - IHC-Prediluted

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Product Details

Summary
Reactivity Hu, EqSpecies Glossary
Applications IHC-P
Clone
66.4.C2 (PN-15)
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
IHC-Prediluted

Renal Cell Carcinoma (gp200) Antibody (66.4.C2 (PN-15)) - IHC-Prediluted Summary

Immunogen
Fresh, normal human renal cortical tissue homogenate was used as immunogen to generate the RCC antibody.
Localization
Cell surface and cytoplasmic
Specificity
Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
LY75
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Tripsin (10 min at 37C) is recommend for antigen retrieval (Bayder & Aydin, 2008).

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
PBS with 0.05% BSA.
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Renal Cell Carcinoma (gp200) Antibody (66.4.C2 (PN-15)) - IHC-Prediluted

  • CD205LY-75
  • CLEC13BLy-75
  • C-type lectin domain family 13 member B
  • DEC-205CD205 antigen
  • GP200-MR6
  • lymphocyte antigen 75

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LY75