Recombinant Mouse HABP1/C1QBP Protein, CF

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

Recombinant Mouse HABP1/C1QBP Protein, CF Summary

Details of Functionality
Measured by its ability to bind human C1q in a functional ELISA.
Source
E. coli-derived mouse HABP1/C1QBP protein
Met-Met Mouse HABP1
(Leu72-Gln279)
Accession # NP_031599
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Met
Protein/Peptide Type
Recombinant Proteins
Gene
C1qbp
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
24.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in MOPS and NaCl with Trehalose.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse HABP1/C1QBP Protein, CF

  • C1q globular domain-binding protein
  • C1QBP
  • complement component 1 Q subcomponent-binding protein, mitochondrial
  • complement component 1, q subcomponent binding protein
  • gC1qBP
  • GC1q-R protein
  • gC1qR
  • gC1Q-R
  • Glycoprotein gC1qBP
  • HABP1
  • HABP1p33
  • Hyaluronan-binding protein 1
  • Mitochondrial matrix protein p32
  • p32
  • SF2p32
  • splicing factor SF2-associated protein

Background

Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). HABP1 is synthesized with a 71 amino acid (aa) N-terminal preproprotein and a 208 aa mature region (3). The 32 kDa mature mouse HABP1, which contains a MAM33-like sequence, shares 90% and 99% aa sequence identity with human and rat HABP1, respectively. HABP1 assembles into a doughnut shaped trimer, with negatively charged residues asymmetrically distributed on one face lining the channel of the complex (4). HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10 - 16). Apoptosis and direct phosphorylation by Erk1/2 induces HABP1 translocation to the nucleus (17).

  1. Thakur, S.C. et al. (2006) J. Androl. 27:604.
  2. Peerschke, E.I.B. and B. Ghebrehiwet (2007) Immunobiology 212:333.
  3. Lynch, N.J. et al. (1997) FEBS Lett. 418:111.
  4. Jiang, J. et al. (1999) Proc. Natl. Acad. Sci. 96:3572. 
  5. Rozanov, D.V. et al. (2002) J. Biol. Chem. 277:9318. 
  6. Deb, T.B. and K. Datta (1996) J. Biol. Chem. 271:2206. 
  7. Lim, B.L. et al. (1996) J. Biol. Chem. 271:26739. 
  8. Grebrehiwet, B. et al. (1994) J. Exp. Med. 179:1809. 
  9. Waggoner, S.N. et al. (2007) J. Leukoc. Biol. 82 epub. 291:829.
  10. Innamorati, G. et al. (2006) Cell. Signal. 18:761.
  11. Robles-Flores, M. et al. (2002) J. Biol. Chem. 277:5247.
  12. Sunayama, J. et al. (1994) Cell Death Differ. 11:771.
  13. Pupo, A.S. and K.P. Minneman (2003) J. Recept. Signal Transduct. Res. 23:185.
  14. Schaerer, M.T. et al. (2001) J. Biol. Chem. 276:26597.
  15. Peterson-Mahrt, S.K. et al. (1999) EMBO J. 18:1014.
  16. Chattopadhyay, C. et al. (2004) Nucleic Acids Res. 32:3632.
  17. Majumdar, M. et al. (2002) Biochem. Biophys. Res. Commun. 291:829.

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Bioinformatics

Gene Symbol C1qbp
Uniprot