Recombinant Human OTUD3 Catalytic Domain Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

Order Details

Recombinant Human OTUD3 Catalytic Domain Protein, CF Summary

Details of Functionality

Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human OTUD3 Catalytic Domain concentration of 0.05-0.5 μM.

Source
E. coli-derived human OTUD3 protein
Glu52 - Gly275
Accession #
Protein/Peptide Type
Recombinant Enzymes
Gene
OTUD3
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain

Applications/Dilutions

Theoretical MW
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using
E-574 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
Buffer

1.3 mg/ml (50 μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 10 % Glycerol (v/v), 1 mM TCEP

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human OTUD3 Catalytic Domain Protein, CF

  • DUBA4
  • KIAA0459
  • OTU domain containing 3
  • OTUD3

Background

OTU domain-containing protein 3 (OTUD3) is a specialized cysteine protease and a member of the ovarian tumor (OTU) protein super-family with a predicted molecular weight of 45 kDa. The human protein shares 83% amino acid sequence identity with its mouse ortholog. OTUD3 is exceedingly well characterized in terms of the structure-function relationship that results in the enzymes preferred polyubiquitin substrates. This untagged recombinant protein contains the catalytic (OTU) and UBA-like (Ubiquitin Associated) domains of OTUD3, and demonstrates a strong preference for K6- and K11-linked polyubiquitin chains.

  1. Mevissen, T.E.T. et al. (2013) Cell 154: 169

Publications for OTUD3 (E-574)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.


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Bioassay
(1)
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Human
(1)
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Bioinformatics Tool for OTUD3 (E-574)

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Bioinformatics

Gene Symbol OTUD3
Entrez
Uniprot