Recombinant Human NRG1 Isoform SMDF Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human NRG1 Isoform SMDF Protein Summary

Details of Functionality
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is 1-5 ng/mL.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human Neuregulin-1 Isoform SMDF protein
Met1-Glu296, Leu117-Glu296 & Ala162-Glu296, each with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Met1, Leu117 & Ala162
Protein/Peptide Type
Recombinant Proteins
Gene
NRG1
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<1.0 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
25-45 kDa, reducing conditions
Publications
Read Publications using
378-SM in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human NRG1 Isoform SMDF Protein

  • ARIA
  • GGF
  • GGF2
  • HGL
  • HRG
  • HRG1
  • HRGA
  • MST131
  • MSTP131
  • NDF
  • Neuregulin1 Isoform SMDF
  • Neuregulin-1 Isoform SMDF
  • NRG1-IT2
  • SMDF

Background

The heregulin (also known as neuregulin) family of cytokines is comprised of multiple secreted or membrane-bound isoforms that are produced from the single heregulin gene by alternative splicing and/or usage of different promoters. All heregulin family members share an epidermal growth factor (EGF)-like domain ( alpha - or beta -variant) that interacts with the erbB family of tyrosine kinase receptors. NRG1 Isoform SMDF is a heregulin isoform containing a C-terminal EGF-like domain ( beta -variant) and a unique N-terminal sequence that lacks an Ig-like domain which is present in all other known heregulins. NRG1 Isoform SMDF also lacks a transmembrane domain and the cytoplasmic tail. NRG1 Isoform SMDF expression has been found to be restricted to the nervous system. It is likely that NRG1 Isoform SMDF may play an important role in neural-specific functions.

  1. Yarden, Y. and D. Wen (1994) in Guidebook to Cytokines and Their Receptors,
  2. N.A. Nicola, Ed., Oxford University Press, p. 146.
  3. Meyer, D. et al. (1997) Development 124:3575.

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Publications for Neuregulin-1 Isoform SMDF (378-SM)(4)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.


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Bioassay
(3)
In Vivo
(1)
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Human
(2)
Mouse
(2)
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Bioinformatics

Gene Symbol NRG1
Uniprot