Recombinant Human FAM105B/OTULIN Protein, CF


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Product Details

Reactivity HuSpecies Glossary
Applications Enzyme Activity

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Recombinant Human FAM105B/OTULIN Protein, CF Summary

Details of Functionality
Recombinant Human FAM105B/OTULIN is a Linear Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human FAM105B/OTULIN concentration of 0.05-1 μM.
E. coli-derived human FAM105B/OTULIN protein
Accession #
Protein/Peptide Type
Recombinant Enzymes
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain


Theoretical MW
40 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publication using
E-558 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
X mg/ml (X μM) in 50 mM HEPES pH 8.0, 100 mM NaCl, 10% glycerol.
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human FAM105B/OTULIN Protein, CF

  • FAM105B family with sequence similarity 105, member B
  • FAM105B


FAM105B ("OTULIN") is a C65 type peptidase and a member of the ovarian tumor (OTU) protein super-family.  OTULIN has exquisite specificity for linear (methionine-1-linked) ubiquitin linkages and has been shown to play a role in the regulation of NF-kB mediated signaling.

  1. Keusekotten, K. et al.  (2013) Cell 153: 1312.
  2. Mevissen, T.E. et al. (2013) Cell 154: 169.
  3. Radjacommare, R. et al. (2014) Front Plant Sci. 5: 84.

Publications for FAM105B/OTULIN (E-558)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Bioassay.

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Bioinformatics Tool for FAM105B/OTULIN (E-558)

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Gene Symbol OTULIN