Recombinant Human alpha-Synuclein Low Endotoxin Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human alpha-Synuclein Low Endotoxin Protein, CF Summary

Details of Functionality
Recombinant Human alpha -Synuclein is ideal for use as a control substrate for in vitro Ubiquitin conjugation using select Ubiquitin E3 ligases such as CHIP/Stub1.  Reaction conditions will need to be optimized for each specific application.
Source
E. coli-derived human alpha-Synuclein protein
Accession #
Protein/Peptide Type
Recombinant Proteins
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Applications/Dilutions

Theoretical MW
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 24 months from date of receipt, -70 °C as supplied.
  • 3 months, -70 °C under sterile conditions after opening.
Buffer
X mg/ml (X μM) in 50 mM HEPES pH 7.5, 100 mM NaCl, 10% (v/v) Glycerol, 2 mM TCEP
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human alpha-Synuclein Low Endotoxin Protein, CF

  • alpha-Synuclein
  • Lewy body) 4
  • MGC110988
  • NACP
  • non A-beta component of AD amyloid
  • Non-A beta component of AD amyloid
  • Non-A4 component of amyloid precursor
  • non-A4 component of amyloid
  • PARK1
  • PARK4
  • SNCA
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Synuclein-alpha

Background

alpha -Synuclein is a member of a family of small, soluble proteins that also include beta -, and gamma -Synuclein.
alpha -Synuclein is predominantly expressed in neurons of the central nervous system, specifically in the presynaptic region of nerve terminals.  This protein cycles between a free, partially unfolded form and a helical, membrane-bound form.  alpha -Synuclein can aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates.  The fibrils and amyloidal forms are major components of Lewy Bodies and have been linked to the pathogenesis of Parkinson's disease dementia.  alpha -Synuclein aggregates can also be found associated with amyloid plaques in Alzheimer's disease.
  1. Breydo L., Wu J.W., Uversky V.N. (2012) Biochim Biophys Acta  1822: 261
  2. Chen R.H. et al.  (2013) J. Biol. Chem.  288: 7438
  3. Li X. et al. (2008)  Acta. Biochim Biophys Sin (Shanghai)  40: 406
  4. Surguchov A. (2008)  Int Rev Cell Mol. Biol.  270: 225
  5. Xia Q. et al.  (2008)  Front Biosci.  13: 3850

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FAQs for alpha-Synuclein (SP-486). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an alpha-Synuclein antibody with an epitope located in the first half (N-terminus) of the protein - preferably a monoclonal antibody. Can you help me with that?
    • Please take a look at NB110-57475. It has been validated for human, rat and mouse and the applications ICC and WB and the epitope it detects is in the N terminal.

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