RAIDD/CRADD Antibody

Images

 
Western Blot: RAIDD Antibody [NBP1-47073] - Western blot analysis of RAIDD in whole cell lysates from HeLa (H) or K562 (K) cells with anti-RAIDD at 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: RAIDD Antibody [NBP1-47073] - Immunocytochemistry of RAIDD in HeLa cells with anti-RAIDD at 5 ug/ml.

Product Details

Summary
Product Discontinued
View other related RAIDD/CRADD Primary Antibodies

Order Details


    • Catalog Number
      NBP1-47073
    • Availability
      Product Discontinued

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RAIDD/CRADD Antibody Summary

Immunogen
Rabbit anti-RAIDD polyclonal antibody was raised against a peptide corresponding to amino acids near the center of human RAIDD
Clonality
Polyclonal
Host
Rabbit
Gene
CRADD
Purity
IgG purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000

Reactivity Notes

human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.05% Sodium Azide
Purity
IgG purified

Alternate Names for RAIDD/CRADD Antibody

  • CASP2 and RIPK1 domain containing adaptor with death domain
  • Caspase and RIP adapter with death domain
  • caspase and RIP adaptor with death domain
  • CRADD
  • death domain containing protein CRADD
  • death domain-containing protein CRADD
  • MGC9163
  • RAIDD
  • RAIDDdeath adaptor molecule RAIDD
  • RIP-associated ICH1/CED3-homologous protein with death domain
  • RIP-associated protein with a death domain

Background

Apoptosis is triggered by activation of initiator caspases upon complex-mediated clustering of the inactive zymogen, as occurs in the caspase-9-activating apoptosome complex. Activation of caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD (1). RAIDD has a dual-domain structure similar to that of FADD. It has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. RAIDD is constitutively expressed in many tissues and thus could play a role in regulating apoptosis in mammalian cells (2). In metazoan cells there exists inactive polypeptide precursors (zymogens), each composed of a prodomain, which is cleaved to activate the protease, and a large and small catalytic subunit. The coupling of these 'death' proteases to signaling pathways is probably mediated by adaptor molecules that contain protein-protein interaction motifs such as the death domain (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Contact Information

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Bioinformatics

Gene Symbol CRADD
Entrez