RAGE RNAi

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications RNAi, RNAi SP

Order Details

RAGE RNAi Summary

Specificity
renal tumor antigen (RAGE), mRNA
Gene
MOK

Applications/Dilutions

Application Notes
This RNAi causes protein knockdown.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for RAGE RNAi

  • AGER
  • EC 2.7.11.22
  • MOK protein kinase
  • MOKMAPK/MAK/MRK overlapping kinase
  • RAGE
  • RAGE-1
  • RAGE1renal cell carcinoma antigen (MOK protein kinase)
  • Renal tumor antigen 1
  • renal tumor antigen

Background

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. RNAi are guaranteed for 3 months from date of receipt.

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Publications for RAGE RNAi (H00005891-R02) (0)

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FAQs for RAGE RNAi (H00005891-R02). (Showing 1 - 1 of 1 FAQ).

  1. Can I use RAGE RNAi in J-774 and THP-1 macrophages? If yes, do you have a step by step protocol?
    • This actually happens to be a product that we distribute for a Taiwanese company called Abnova. They do all of their testing in house and it looks like they have only tested so far in 293 cells. For your reference, here is the protocol that they used.

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Five Funny Protein Names: Infographic
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For Inflammation Research, S100A12 is all the RAGE
S100A12 (Calgranulin C) belongs to the S100 family of calcium-binding proteins. The 20 members of this group share EF-hand domains which are involved in binding of calcium. S100A12 is expressed by granulocytes, whereas its expression by monocytes rema...  Read full blog post.

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Bioinformatics

Gene Symbol MOK
Entrez