RAGE Antibody

Images

 
Western Blot: RAGE Antibody [NBP1-19732] Extracts from HEK293A cells.
Immunohistochemistry-Paraffin: RAGE Antibody [NBP1-19732] - Human lung carcinoma tissue.
Western Blot: RAGE Antibody [NBP1-19732] - extracts from LOVO cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-19732
    • Availability
      Product Discontinued

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RAGE Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 150-205 of Human AGER / RAGE.
Clonality
Polyclonal
Host
Rabbit
Gene
MOK
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of RAGE (E182) pAb in extracts from HEK293A cells.
Immunohistochemistry (IHC) analyzes of RAGE (E182) pAb in paraffin-embedded human lung carcinoma tissue.
Theoretical MW
43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
15mM Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RAGE Antibody

  • AGER
  • EC 2.7.11.22
  • MOK protein kinase
  • MOKMAPK/MAK/MRK overlapping kinase
  • RAGE
  • RAGE-1
  • RAGE1renal cell carcinoma antigen (MOK protein kinase)
  • Renal tumor antigen 1
  • renal tumor antigen

Background

Advanced glycosylation end products of proteins (AGEs) are nonenzymatically glycosylated proteins that are associated with a variety of conditions including diabetes and other vascular disorders, as well as amyloidosis. These proteins regulate cellular functions via specific cell surface acceptor molecules, such as RAGE (receptor for advanced glycosylation end products). RAGE is a type 1 membrane protein that is found on the surface of endothelial cells, mononuclear phagocytes and vascular smooth muscle cells. Binding of AGEs to RAGE results in the induction of cellular oxidant stress and activation of the transcription factor NFkappaB. Evidence suggests that the induction of oxidant stress results in the activation of an intracellular cascade involving p21 Ras and MAP kinase, which leads to activation of transcription.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for RAGE Antibody (NBP1-19732)

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Research Areas for RAGE Antibody (NBP1-19732)

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Blogs on RAGE.

Five Funny Protein Names: Infographic
Some proteins have the strangest names. Check out our list for some of the funniest ones and learn more about each protein including their function, gene symbol, molecular weight and family.Novus Biologicals offers reagents for each target:Merli...  Read full blog post.

For Inflammation Research, S100A12 is all the RAGE
S100A12 (Calgranulin C) belongs to the S100 family of calcium-binding proteins. The 20 members of this group share EF-hand domains which are involved in binding of calcium. S100A12 is expressed by granulocytes, whereas its expression by monocytes rema...  Read full blog post.

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Bioinformatics

Gene Symbol MOK
Entrez