Recombinant Human RAG2 Protein Summary
A recombinant protein with GST tag at N-terminal corresponding to the amino acids 428-527 of Human RAG2 partial ORF
Source: Wheat Germ (in vitro)
Amino Acid Sequence:NTWVPFYSTELNKPAMIYCSHGDGHWVHAQCMDLAERTLIHLSAGSNKYYCNEHVEIARALHTPQRVLPLKKPPMKSLRKKGSGKILTPAKKSFLRRLFD
|Details of Functionality
This protein is not active and should not be used for experiments requiring activity.
| Protein/Peptide Type
Partial Recombinant Protein
This protein has not been tested for any functionality. Product may contain endotoxins and is not suitable for use with live cells.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Recombinant Human RAG2 Protein
- recombination activating gene 2
- V(D)J recombination-activating protein 2
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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