Rad17 [p Ser645] Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-92703
    • Availability
      Product Discontinued

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Rad17 [p Ser645] Antibody Summary

Immunogen
Synthetic phosphopeptide derived from human Rad17 around the phosphorylation site of Serine 645.
Modification
p Ser645
Clonality
Polyclonal
Host
Rabbit
Gene
RAD17
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analyzes of p-Rad17 (S645) antibody in extracts from HeLa cells treated with UV.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Rad17 Lysate (NBL1-15111)

Reactivity Notes

This antibody is reactive against Human,Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Rad17 [p Ser645] Antibody

  • CCYC
  • cell cycle checkpoint protein (RAD17)
  • cell cycle checkpoint protein RAD17
  • FLJ41520
  • HRAD17
  • R24L
  • RAD1 (S. pombe) homolog
  • RAD1 homolog
  • RAD17 homolog (S. pombe)
  • Rad17
  • Rad17-like protein
  • RAD17SP
  • RAD24
  • RF-C activator 1 homolog
  • RF-C/activator 1 homolog

Background

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe Rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA damage induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol RAD17
Entrez