PTPN6 Antibody

Images

 
Western Blot: PTPN6 Antibody [NB100-58968] - (0.1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

PTPN6 Antibody Summary

Immunogen
Peptide with sequence C-KASRTSSKHKEE corresponding to internal region according to NP_002822.2.
Epitope
KASRTSSKHKEE
Specificity
This antibody is expected to recognise both reported isoforms (NP_536858.1and NP_002822.2). Please note this antibody was designed using the mouse sequence, which differs by 1 amino acid from the human sequence.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PTPN6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Peptide ELISA Detection limit 1:128000
Application Notes
WB: Approx. 65 kDa band observed in human bone marrow and liver lysates and in mouse and rat spleen and thymus lysates (calculated MW of 67.6 kDa band according to NP_536858.1and NP_002822.2).
Positive Control
Liver Lysate (NB820-59232)
PTPN6 Lysate (NBL1-14976)
Publications
Read Publication using NB100-58968.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Canine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PTPN6 Antibody

  • HCPH
  • HCPSH-PTP1
  • hematopoietic cell phosphatase
  • Hematopoietic cell protein-tyrosine phosphatase
  • HPTP1C
  • protein tyrosine phosphatase, non-receptor type 6
  • Protein-tyrosine phosphatase 1C
  • Protein-tyrosine phosphatase SHP-1
  • PTP1C
  • PTP-1CEC 3.1.3.48
  • SHP1
  • SHP-1
  • SHP-1L
  • tyrosine-protein phosphatase non-receptor type 6

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PTPN6 Antibody (NB100-58968)(1)


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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PTPN6
Entrez
Uniprot