PTPN6 Antibody

Images

 
Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in mouse spleen.
Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in HeLa.
Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in human pancreas.
Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in mouse lung.
Western Blot: PTPN6 Antibody [H00005777-D01P] - Analysis of PTPN6 expression in transfected 293T cell line by PTPN6 polyclonal antibody.Lane 1: PTPN6 transfected lysate(67.60 KDa).Lane 2: Non-transfected lysate.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

PTPN6 Antibody Summary

Immunogen
PTPN6 (NP_002822.2, 1 a.a. - 595 a.a.) full-length human protein. MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTPN6
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
It has been used for WB.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein G purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PTPN6 Antibody

  • HCPH
  • HCPSH-PTP1
  • hematopoietic cell phosphatase
  • Hematopoietic cell protein-tyrosine phosphatase
  • HPTP1C
  • protein tyrosine phosphatase, non-receptor type 6
  • Protein-tyrosine phosphatase 1C
  • Protein-tyrosine phosphatase SHP-1
  • PTP1C
  • PTP-1CEC 3.1.3.48
  • SHP1
  • SHP-1
  • SHP-1L
  • tyrosine-protein phosphatase non-receptor type 6

Background

SHP-1 (also called PTP1C, SH-PP1, HCP, SHP and PTPN6) is a protein tyrosine phosphatase (PTP) predominantly expressed in hematopoietic cells, and regulates multiple signaling pathways involved in hematopoietic cell growth, differentiation and activation (1). After cell stimulation, SHP-1 (as well as SHP-2), translocate from cytosol to plasma membrane and bind to the tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). SHP-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-Kit, CSF-1, EGF), cytokine receptors (IL-3, IFN-a/b) and other tyrosine based receptor CD22, B & T cell Ag receptor, Lck, Zap-70 and Vav (3-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PTPN6
Uniprot