PTPN13/PTPL1 Antibody

Images

 
Immunohistochemistry-Paraffin: PTPN13/PTPL1 Antibody [NBP1-02579] - Staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

PTPN13/PTPL1 Antibody Summary

Immunogen
Synthetic peptide from human PTPN13.
Specificity
Amino acids 2451 to 2466 of human PTPN13
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTPN13
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for PTPN13/PTPL1 Antibody

  • EAP-1
  • FAP-1
  • hPTPE1
  • PNP1
  • protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associatedphosphatase)
  • protein-tyrosine phosphatase 1, Fas-associated
  • PTP1E
  • PTP1EDKFZp686J1497
  • PTP-BAS
  • PTP-BASEC 3.1.3.48
  • PTP-BL
  • PTP-E1
  • PTPL1
  • PTPL1nonreceptor type 13
  • PTPLE
  • PTPN13
  • tyrosine-protein phosphatase non-receptor type 13

Background

Fas-associated phosphatase-1 (FAP-1), a NT7 non-receptor protein tyrosine phosphatase, is comprised of a N-terminal FERM domain, five PDZ domains, and a C-terminal tyrosine phosphatase domain. The protein has been shown to bind the cytosolic tail of Fas (Apo1, CD95) and regulate Fas-induced apoptosis. Human tumor cell lines become resistant to Fas-mediated apoptosis when transfected with FAP-1, indicating that FAP-1 functions as a negative regulator in Fas-mediated death signaling. FAS resistance has been documented in a variety of cancers, including cancer of the lung, ovary, pancreas, and liver. At least three protein isoforms of FAP-1 have been reported. Alterations in FAP-1 expression have been shown to result in defects in cytokinesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PTPN13
Entrez
Uniprot