PTP1B/PTPN1 Antibody (OTI1A2)


Western Blot: PTPN1 Antibody (1A2) [NBP2-00849] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates more
Immunocytochemistry/ Immunofluorescence: PTPN1 Antibody (1A2) [NBP2-00849] Staining of COS7 cells transiently transfected by pCMV6-ENTRY PTPN1.
Flow Cytometry: PTPN1 Antibody (1A2) [NBP2-00849] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PTPN1 antibody, and then analyzed more
Flow Cytometry: PTPN1 Antibody (1A2) [NBP2-00849] - Analysis of Hela cells, using anti-PTPN1 antibody, (Red), compared to a nonspecific negative control antibody (Blue).
Flow Cytometry: PTPN1 Antibody (1A2) [NBP2-00849] - Analysis of Jurkat cells, using anti-PTPN1 antibody, (Red), compared to a nonspecific negative control antibody (Blue).

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PTP1B/PTPN1 Antibody (OTI1A2) Summary

Full length recombinant protein of human PTP1B/PTPN1 (NP_002818) produced in HEK293T cells.
Immunogen affinity purified
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  • Western Blot 1:2000
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:100
Theoretical MW
49.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
PTP1B/PTPN1 Lysate (NBP2-64957)

Reactivity Notes


Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
0.02% Sodium Azide
Immunogen affinity purified

Alternate Names for PTP1B/PTPN1 Antibody (OTI1A2)

  • EC
  • protein tyrosine phosphatase 1B
  • protein tyrosine phosphatase, non-receptor type 1
  • Protein-tyrosine phosphatase 1B
  • PTP1B
  • PTP-1B
  • PTP1Bprotein tyrosine phosphatase, placental
  • PTPN1
  • tyrosine-protein phosphatase non-receptor type 1


The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq].


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol PTPN1