PTP1B/PTPN1 Antibody (107AT531)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-50765
    • Availability
      Product Discontinued

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PTP1B/PTPN1 Antibody (107AT531) Summary

Immunogen
Recombinant protein encoding amino acids 1-321 of human PTP1B
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PTPN1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
Application Notes
The antibody can be used for ELISA (0.25 ug/ml) and Western blotting (0.5 - 2.5 ug/ml).

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
0.25 mg/ml
Purity
Protein A or G purified

Alternate Names for PTP1B/PTPN1 Antibody (107AT531)

  • EC 3.1.3.48
  • protein tyrosine phosphatase 1B
  • protein tyrosine phosphatase, non-receptor type 1
  • Protein-tyrosine phosphatase 1B
  • PTP1B
  • PTP-1B
  • PTP1Bprotein tyrosine phosphatase, placental
  • PTPN1
  • tyrosine-protein phosphatase non-receptor type 1

Background

The non-transmembrane protein tyrosine phosphatase, PTP1B, comprises 435 amino acids, of which the C-terminal 114 residues have been implicated in controlling both localization and function of this enzyme. Increased phosphorylation of PTP1B is seen to accompany the transition from G2 to M phase of the cell cycle. Immunofluorescence experiments indicate that PTP-1B is localized predominantly in the endoplasmic reticulum (ER). Subcellular fractionation is consistent with this localization and establishes that PTP-1B is tightly associated with microsomal membranes, with its phosphatase domain oriented towards the cytoplasm. The finding of a tyrosine phosphatase on the ER suggests new possibilities for cellular events controlled by tyrosine phosphorylation (2). It has also been shown that PTP1B is a novel substrate for Akt and that phosphorylation of PTP1B by Akt at Ser(50) may negatively modulate its phosphatase activity creating a positive feedback mechanism for insulin signaling (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Additional PTP1B/PTPN1 Products

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Diseases for PTP1B/PTPN1 Antibody (NBP1-50765)

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Bioinformatics

Gene Symbol PTPN1
Entrez
Uniprot