PSENEN/PEN2 Antibody

Images

 
Western Blot: PSENEN/PEN2 Antibody [NBP1-77267] - K562 cell lysate with PEN2 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunofluorescence: PSENEN/PEN2 Antibody [NBP1-77267] - Immunofluorescence of PEN2 in K562 cells with PEN2 antibody at 20 ug/mL.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

PSENEN/PEN2 Antibody Summary

Immunogen
Antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human PEN2. The immunogen is located within the last 50 amino acids of PEN2.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PSENEN
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000
  • Immunofluorescence 20 ug/ml
Control Peptide
PSENEN/PEN2 Peptide (NBP1-77267PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PSENEN/PEN2 Antibody

  • gamma-secretase subunit PEN-2
  • MSTP064
  • PEN-2
  • PEN2hematopoietic stem/progenitor cells protein MDS033
  • presenilin enhancer 2 homolog (C. elegans)
  • Presenilin enhancer protein 2
  • PSENEN

Background

PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PSENEN
Entrez
Uniprot