Proprotein Convertase 7/PCSK7 Antibody (1B8)

Images

 
Immunocytochemistry/ Immunofluorescence: PCSK7 Antibody (1B8) [NBP2-02106] Staining of COS7 cells transiently transfected by pCMV6-ENTRY PCSK7.
Flow Cytometry: PCSK7 Antibody (1B8) [NBP2-02106] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-PCSK7 antibody, and then analyzed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF
Clone
1B8
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Proprotein Convertase 7/PCSK7 Antibody (1B8) Summary

Immunogen
Full length human recombinant protein of human PCSK7 (NP_004707) produced in HEK293T cell.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
PCSK7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:100
  • Immunocytochemistry/Immunofluorescence 1:100

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Proprotein Convertase 7/PCSK7 Antibody (1B8)

  • EC 3.4.21
  • EC 3.4.21.-
  • EC 3.4.21.61
  • EC 3.4.21.75
  • EC 3.4.21.93
  • hPC8
  • LPC
  • LPCFLJ23503
  • Lymphoma proprotein convertase
  • PC7FLJ45329
  • PC8prohormone convertase PC7
  • PCSK7
  • Prohormone convertase 7
  • Proprotein Convertase 7
  • Proprotein convertase 8
  • proprotein convertase subtilisin/kexin type 7
  • SPC7
  • SPC7proprotein convertase PC7
  • Subtilisin/kexin-like protease PC7

Background

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

ICC/IF Video Protocol

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Bioinformatics

Gene Symbol PCSK7
Entrez