Progesterone R/NR3C3 Antibody (8A11H1)

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Western Blot: Progesterone R/NR3C3 Antibody (8A11H1) [NBP1-51551] - Western blot analysis using PGR mouse mAb against truncated MBP-PGR recombinant protein (1) and truncated Trx-PGR(aa730-871) recombinant protein (2).

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51551
    • Availability
      Product Discontinued

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Progesterone R/NR3C3 Antibody (8A11H1) Summary

Immunogen
Purified recombinant fragment of PGR (aa730-871) expressed in E. Coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PGR
Purity
Unpurified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000
  • ELISA 1:10000

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.03% Sodium Azide
Purity
Unpurified

Alternate Names for Progesterone R/NR3C3 Antibody (8A11H1)

  • NR3C3
  • NR3C3PRNuclear receptor subfamily 3 group C member 3
  • PGR
  • Progesterone R
  • progesterone receptor
  • ProgesteroneR

Background

The human progesterone receptor (PR), is a ligand-activated transcription factor and is a member of the steroid receptor family (1). PR exists in humans as two isoforms; PR-A (94 kDa) which lacks the first 164 amino acids of PR-B and PR-B (114 kDa)(2-3). While the two forms of PR have similar DNA- and ligand-binding affinities they have opposite transcriptional activities. PR-B functions as an activator of progesterone-responsive genes, while PR-A functions as a strong transdominant repressor of PR-B (4). Human progesterone receptor (PR) is phosphorylated on multiple serine residues (at least seven sites) in a manner that involves distinct groups of sites coordinately regulated by hormone and different kinases. As detected by Western blot of T47D cells treated with hormone for different times, hormone-dependent down-regulation of total PR and the Ser 190 phosphorylation site occurred in parallel, whereas the Ser 294 phosphorylation site was down-regulated more rapidly (5)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for Progesterone R/NR3C3 Antibody (NBP1-51551). (Showing 1 - 1 of 1 FAQ).

  1. I am interested in getting antibodies for PR (progesterone receptor) that would work in flow cytometry. Could you recommend some choices?
    • We do not currently have any antibodies directed towards the progesterone receptor that have been validated in flow cytometry, but any of our antibodies that work in ICC should work just fine in flow as they are essentially the same application. Please see this link for our Progesterone Receptor antibodies validated in ICC.

Secondary Antibodies

 

Isotype Controls

Additional Progesterone R/NR3C3 Products

Bioinformatics Tool for Progesterone R/NR3C3 Antibody (NBP1-51551)

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Diseases for Progesterone R/NR3C3 Antibody (NBP1-51551)

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Bioinformatics

Gene Symbol PGR
Entrez