Prion protein Antibody (C16-S)

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Western Blot: Prion protein Antibody (C16-S) [NBP1-71679] - Of a prion protein was performed by Drs. Valeriy Ostapchenko and Marco Prado, Robarts Research Institute, the University of Western Ontario, London, Ontario, ...read more
Western Blot: Prion protein Antibody (C16-S) [NBP1-71679] - analysis of prion protein in mouse brain extract (A), HEK293 cells producing recombinant human prion protein (B), and untransfected HEK 293 cells (C). 200 ug ...read more

Product Details

Summary
Reactivity Hu, Mu, Bv, ShSpecies Glossary
Applications WB, ELISA, IHC, IHC-Fr, IHC-P, IP
Clone
C16-S
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Prion protein Antibody (C16-S) Summary

Immunogen
Peptide derived the C-terminus of third a-helical domain of human prion protein.
Clonality
Monoclonal
Host
Rabbit
Gene
PRNP
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • ELISA 1:20000-1:50000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
This product is used in ELISA 1:20000-1:50000, Western Blot 1:2000. Immunoprecipitation, IHC.
Publications
Read Publication using
NBP1-71679 in the following applications:

  • WB
    1 publication

Reactivity Notes

Human, ovine, bovine, mouse - tested.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris/HCl (pH 8.0) and 10 mg/ml BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Prion protein Antibody (C16-S)

  • CD230
  • CJD
  • fatal familial insomnia)
  • GSS
  • prion protein (p27-30)
  • prion protein PrP
  • prion protein
  • prion-related protein
  • PRIPMGC26679

Background

Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Prion protein Antibody (NBP1-71679)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: WB.


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WB
(1)
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Bioinformatics

Gene Symbol PRNP
Uniprot