Presenilin-1 Antibody

Images

 
Western Blot: Presenilin-1 Antibody [NBP1-59368] - OVCAR-3 cell lysate, Antibody Titration: 0.2-1 ug/ml.
Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NBP1-59368] - Human Brain, cerebellum tissue at an antibody concentration of 4-8ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-59368
    • Availability
      Product Discontinued

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Presenilin-1 Antibody Summary

Immunogen
Synthetic peptides corresponding to PSEN1(presenilin 1) The peptide sequence was selected from the N terminal of PSEN1. Peptide sequence TRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKY.
Clonality
Polyclonal
Host
Rabbit
Gene
PSEN1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.2-1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 4-8 ug/ml
Application Notes
This is a rabbit polyclonal antibody against PSEN1 and was validated on Western blot.
Positive Control
Presenilin-1 Lysate (NBP2-65407)

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS and 2% Sucrose
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Notes

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for Presenilin-1 Antibody

  • AD3EC 3.4.23.-
  • Alzheimer disease 3
  • EC 3.4.23
  • FAD
  • presenilin 1
  • Presenilin1
  • Presenilin-1
  • Protein S182
  • PS-1
  • PS1presenilin-1
  • PSEN1
  • PSNL1
  • S182

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form o

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Presenilin-1 Antibody (NBP1-59368)

Discover related pathways, diseases and genes to Presenilin-1 Antibody (NBP1-59368). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for Presenilin-1 Antibody (NBP1-59368)

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Blogs on Presenilin-1.

Immunity’s flipside: Microglia promote Alzheimer’s pathology during inflammation
By Jamshed Arslan Pharm.D. Microglia are brain's macrophages. In Alzheimer's disease (AD), microglia clear up protein aggregates called amyloid beta plaques. The connection between immune activation and AD is unclea...  Read full blog post.

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Bioinformatics

Gene Symbol PSEN1
Entrez
Uniprot