Presenilin-1 Antibody

Images

 
Western Blot: Presenilin-1 Antibody [NB100-91935] - Analysis of Presenilin 1 (S28) pAb at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Mouse brain tissue lysateLane3:PC12 whole cell lysate
Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NB100-91935] - Analyzes of Presenilin -1 (S28) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.
Western Blot: Presenilin-1 Antibody [NB100-91935] - Analysis of Presenilin- 1 (S28) antibody in extracts from mouse heart cells.
Western Blot: Presenilin-1 Antibody [NB100-91935] - Analysis of Presenilin -1 (S28) pAb at 1:500 dilutionLane1:SGC7901 whole cell lysate(40ug)Lane2:PC3 whole cell lysate(40ug)Lane3:U-87MG whole cell lysate(40ug)Lane4:C6 ...read more
Immunohistochemistry-Paraffin: Presenilin-1 Antibody [NB100-91935] - Analyzes of Presenilin- 1 (S28) antibody in paraffin-embedded human brain tissue.

Product Details

Summary
Product Discontinued
View other related Presenilin-1 Primary Antibodies

Order Details


    • Catalog Number
      NB100-91935
    • Availability
      Product Discontinued

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Presenilin-1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids N-terminus of Human PSEN1.
Clonality
Polyclonal
Host
Rabbit
Gene
PSEN1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Presenilin 1 (S28) pAb in extracts from mouse heart cells.
Immunohistochemistry (IHC) analyzes of Presenilin 1 (S28) pAb in paraffin-embedded human brain tissue.
Theoretical MW
52 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Presenilin-1 Antibody

  • AD3EC 3.4.23.-
  • Alzheimer disease 3
  • EC 3.4.23
  • FAD
  • presenilin 1
  • Presenilin1
  • Presenilin-1
  • Protein S182
  • PS-1
  • PS1presenilin-1
  • PSEN1
  • PSNL1
  • S182

Background

A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer's disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80% amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer's disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Bioinformatics

Gene Symbol PSEN1
Entrez