Presenilin-1 Antibody

Images

 

Product Details

Summary
Product Discontinued
View other related Presenilin-1 Primary Antibodies

Order Details


    • Catalog Number
      NB100-64822
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

Presenilin-1 Antibody Summary

Immunogen
N-terminus peptide (amino acids 14-33) of presenilin-1.
Specificity
Recognizes human presenilin-1, a protein that has been linked with an early onset form on Alzheimer's disease. Presenilin-1 is a membrane protein whose function is, as yet, undetermined.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
PSEN1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Immunohistochemistry-Frozen and Paraffin, ELISA and Western Blot This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.

Reactivity Notes

Reacts with Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.09% Sodium Azide
Purity
Unpurified

Alternate Names for Presenilin-1 Antibody

  • AD3EC 3.4.23.-
  • Alzheimer disease 3
  • EC 3.4.23
  • FAD
  • presenilin 1
  • Presenilin1
  • Presenilin-1
  • Protein S182
  • PS-1
  • PS1presenilin-1
  • PSEN1
  • PSNL1
  • S182

Background

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2). Presenilins form the catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Evidence suggests cleavage of APP by gamma-secretase and the production of Abeta (42 aa) is likely to play a important or casual role in the development of Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP2-13075
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP, IHC-FrFl
NB100-74512
Species: Hu, Mu, Rt, Pm
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP1-90813
Species: Hu
Applications: WB, IHC, IHC-P
MAB931
Species: Hu, Mu
Applications: WB, IHC, CyTOF-ready, ICFlow
NB110-60531
Species: Hu, Mu, Rt(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, IP, CyTOF-ready
NBP2-25162
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
44110002
Species: Hu
Applications: WB, ELISA, ICC/IF
NBP2-24611
Species: Hu, Mu, Rt, Bv, Ca, Eq, Op
Applications: WB
NBP1-77270
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IF
NB100-74360
Species: Hu, Mu
Applications: WB, ChIP, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NBP1-31302
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-16684
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
NB100-56503
Species: Hu, Mu, Rt, Po, Ca, Dr, Eq, Ma, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-P
NBP1-54467
Species: Hu, Mu, Rt, Ch, Pm
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P, IP
NBP1-84304
Species: Hu
Applications: WB, IHC, IHC-P
NB100-78486
Species: Hu, Mu, Rt(-)
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, CyTOF-ready
NBP1-81838
Species: Hu, Mu
Applications: WB, IHC, IHC-P
NB100-64822
Species: Hu
Applications: WB, ELISA, IHC, IHC-Fr, IHC-P

Publications for Presenilin-1 Antibody (NB100-64822) (0)

There are no publications for Presenilin-1 Antibody (NB100-64822).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Presenilin-1 Antibody (NB100-64822) (0)

There are no reviews for Presenilin-1 Antibody (NB100-64822). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Presenilin-1 Antibody (NB100-64822) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Presenilin-1 Products

Bioinformatics Tool for Presenilin-1 Antibody (NB100-64822)

Discover related pathways, diseases and genes to Presenilin-1 Antibody (NB100-64822). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Presenilin-1 Antibody (NB100-64822)

Discover more about diseases related to Presenilin-1 Antibody (NB100-64822).
 

Pathways for Presenilin-1 Antibody (NB100-64822)

View related products by pathway.

PTMs for Presenilin-1 Antibody (NB100-64822)

Learn more about PTMs related to Presenilin-1 Antibody (NB100-64822).
 

Research Areas for Presenilin-1 Antibody (NB100-64822)

Find related products by research area.

Blogs on Presenilin-1

There are no specific blogs for Presenilin-1, but you can read our latest blog posts.

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Presenilin-1 Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol PSEN1
Entrez
Uniprot