PRCC Antibody

Images

 
Immunohistochemistry: PRCC Antibody [NBP1-28704] - Sample: FFPE section of human breast carcinoma. Antibody used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Immunoprecipitation: PRCC Antibody [NBP1-28704] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PRCC antibody NBP1-28704 used for IP at 3 ug/mg ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-28704
    • Availability
      Product Discontinued

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PRCC Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 125 and 175 of human papillary renal cell carcinoma (translocation-associated) using the numbering given in entry NP_005964.3 (GeneID 5546).
Clonality
Polyclonal
Host
Rabbit
Gene
PRCC
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:1000
  • Immunoprecipitation 2-5 ug/mg lysate
Application Notes
This antibody is useful for immunoprecipitation. It is not recommended for western analysis.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PRCC Antibody

  • MGC17178
  • papillary renal cell carcinoma (translocation-associated)
  • Papillary renal cell carcinoma translocation-associated gene protein
  • proline-rich protein PRCC
  • RCCP1MGC4723
  • TPRC

Background

In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PRCC
Entrez
Uniprot