PPP4C Antibody

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Western Blot: PPP4C Antibody [NBP1-55248] - Human Muscle lysate, concentration 0.2-1 ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-55248
    • Availability
      Product Discontinued

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PPP4C Antibody Summary

Immunogen
Synthetic peptides corresponding to PPP4C(protein phosphatase 4 (formerly X), catalytic subunit) The peptide sequence was selected from the middle region of PPP4C. Peptide sequence TVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKP.
Clonality
Polyclonal
Host
Rabbit
Gene
PPP4C
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Application Notes
This is a rabbit polyclonal antibody against PPP4C and was validated on Western blot.
Theoretical MW
34 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS and 2% Sucrose
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Notes

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for PPP4C Antibody

  • EC 3.1.3.16
  • Pp4
  • PP4C
  • PP4protein phosphatase X, catalytic subunit
  • PPP4
  • PP-X
  • PPXPPH3
  • protein phosphatase 4 (formerly X), catalytic subunit
  • protein phosphatase 4, catalytic subunit
  • Protein phosphatase X
  • serine/threonine-protein phosphatase 4 catalytic subunit

Background

PPP4C is a protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDC2/Cdk1 phosphorylation sites and negatively regulates CDC2/Cdk1 activity in interphase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for PPP4C Antibody (NBP1-55248). (Showing 1 - 1 of 1 FAQ).

  1. The antibody I am looking for is the anti-mouse PP4C. We have been using an old antibody from your company (Rabbit polyclonal to PPP4C, catalog # NB100-2874), which I assume is discontinued, as I could not find it on your website. As I have mentioned to you, I am looking for PP4C (anti-mouse) antibodies for IP and IHC. I appreciate it if you can inform me of any of your antibody products suitable for these applications, and available at an affordable trial size.
    • NB110-40495 is an anti-PPP4C antibody that has been validated in Western blot, ICC, IHC on paraffin-embedded tissues and immunoprecipitation on human and mouse samples.

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Bioinformatics

Gene Symbol PPP4C
Uniprot