PMS2 Antibody

Images

 
Western Blot: PMS2 Antibody [NBP1-58274] - HeLa extract Dilution: 1:1000.
Western Blot: PMS2 Antibody [NBP1-58274] - HepG2 cell lysate, 0.2-1 ug/ml.

Product Details

Summary
Product Discontinued
View other related PMS2 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-58274
    • Availability
      Product Discontinued

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PMS2 Antibody Summary

Immunogen
Synthetic peptides corresponding to PMS2(PMS2 postmeiotic segregation increased 2 (S. cerevisiae)) The peptide sequence was selected from the middle region of PMS2. Peptide sequence INKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA.
Clonality
Polyclonal
Host
Rabbit
Gene
PMS2
Purity
Immunogen affinity purified
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Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
PBS and 2% Sucrose
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Application Notes
This is a rabbit polyclonal antibody against PMS2 and was validated on Western blot.

Notes

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for PMS2 Antibody

  • DNA mismatch repair protein PMS2
  • EC 3.1
  • H_DJ0042M02.9
  • HNPCC4postmeiotic segregation increased (S. cerevisiae) 2
  • mismatch repair endonuclease PMS2
  • PMS1 protein homolog 2
  • PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
  • PMSL2PMS2CL

Background

PMS2 is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors.This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on PMS2

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol PMS2
Uniprot

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