PMP70 Antibody

Product Discontinued

PMP70 Antibody Summary

• Immunogen: Synthetic peptide: CN(644)YEFKKITEDTVEFGS(659).Immunizing peptide corresponds to amino acid residues 644-659 from rat PMP 70.
• Marker: Proxisomal Membrane Marker
• Specificity: PMP70 - Proxisomal Membrane Marker
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ABCD3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:2000
  • Western Blot 1:500

Reactivity Notes

Mouse. This sequence differs from human PMP 70 by a single amino acid substitution.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS, 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PMP70 Antibody

• 70 kDa peroxisomal membrane protein
• ABC43
• ATP-binding cassette, sub-family D (ALD), member 3
• peroxisomal membrane protein 1 (70kD, Zellweger syndrome)
• Peroxisomal membrane protein-1 (70kD)
• PMP70ATP-binding cassette sub-family D member 3
• PXMP1dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))
• ZWS2

Background

Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum's disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PMP70 Antibody (NB110-5118)(1)

Publication using NB110-5118

• Waring, J F, Y Yang et al. Gene Expression Analysis in Rats Treated with Experimental Acetyl-Coenzyme A Carboxylase Inhibitors Suggests Interactions with the Peroxisome Proliferator-Activated Receptor {alpha} Pathway. J Pharmacol Exp Ther 324: 507-516. 2008-01-01 [PMID: 18025247]

Bioinformatics

• Gene Symbol: ABCD3
• Entrez:
  • 19299(Mouse)
  • 25270(Rat)
• Uniprot:
  • P16970(Rat)