PMP22 Antibody (CF1)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51693
    • Availability
      Product Discontinued

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PMP22 Antibody (CF1) Summary

Immunogen
Peptide corresponding to amino acids 121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue (CRHPEWHLNSDYSYG).
Marker
Schwann Cell Marker
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PMP22
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunoassay
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Reacts with Human. Cross reacts with Primate.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
0.02% Sodium Azide
Purity
Protein A or G purified

Alternate Names for PMP22 Antibody (CF1)

  • CMT1A
  • CMT1E
  • GAS3
  • GAS-3DSS
  • growth arrest-specific 3
  • Growth arrest-specific protein 3
  • HMSNIA
  • HNPP
  • MGC20769
  • peripheral myelin protein 22
  • PMP-22
  • Sp110

Background

The monoclonal antibody CF1 recognizes human peripheral myelin protein 22 (PMP22). PMP22 is a 160 amino acid glycoprotein and contains four hydrophobic domains, presumably transmembrane regions. It is the second most abundant protein in the mammalian nervous system, but is, at least in rodents, also found in other tissues, including the liver and gut. Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy. Monoclonal antibody CF1 is crossreactive with Rhesus monkey PMP22.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics Tool for PMP22 Antibody (NBP1-51693)

Discover related pathways, diseases and genes to PMP22 Antibody (NBP1-51693). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for PMP22 Antibody (NBP1-51693)

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Research Areas for PMP22 Antibody (NBP1-51693)

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Blogs on PMP22.

PMP22 Antibodies Assist in PNS Myelin Repair Research
Novus Biologicals recently added a new  PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene.Th...  Read full blog post.

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Bioinformatics

Gene Symbol PMP22