PLVAP Antibody (174/2)

Images

 

Product Details

Summary
Product Discontinued
View other related PLVAP Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51694
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

PLVAP Antibody (174/2) Summary

Immunogen
74/2 reacts with human plasmalemma vesicle associated protein (PLVAP)
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PLVAP
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Functional
  • Immunoassay

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
0.2% Sodium Azide
Purity
Protein A or G purified

Alternate Names for PLVAP Antibody (174/2)

  • FELS
  • FELSfenestrated-endothelial linked structure protein; PV-1 protein
  • Fenestrated endothelial-linked structure protein
  • gp68
  • plasmalemma vesicle associated protein
  • PLVAP
  • PV1
  • PV-1
  • PV1Plasmalemma vesicle protein 1
  • PV-1plasmalemma vesicle-associated protein

Background

The monoclonal antibody 60.11 recognizes a cell membrane C1q binding molecule that recognises the globular heads of C1q. It is also present in plasma and the extracellular matrix. The molecule is an unusually acidic, single chain protein with an apparent molecular weight of 33 kDa. It does not possess a conventional sequence motif compatible with a membrane spanning segment nor a consensus site for a GPI anchor. gC1q-R migrates as a single chain under both reducing and non-reducing conditions, but it behaves as an oligomer on gel-filtration in non-dissociating conditions. Its multimer formation may be a critical process by which the gC1q-R molecule increases its affinity for multivalent ligands such as C1q. gC1q-R has been shown to inhibit complement activation by preventing the binding of C1q to antibodies, suggesting that the binding site for gC1q-R and the binding site for immune complexes, which are present on the C1q globular ‘heads’, may be located at the same position. gC1q-R is capable of interacting with several proteins involved in blood clotting, namely, thrombin, prothrombin, the heparinbinding form of vitronectin, the ternary complex, vitronectin-thrombin-antithrombin, as well as high-molecular-weight kininogen and Hageman factor. Besides its role in the complement pathway, gC1q-R participates in enhancement of Fc-receptor and CR1-mediated phagocytosis, procoagulant activity on platelets, and chemotactic activity on mast cells, eosinophils, neutrophils, and fibroblasts. gC1q-R is expressed on a wide variety of cells and can serve as a binding site for plasma and microbial proteins. Its antigenic sites may be cryptic on cells in suspension but become exposed when the cells are fixed by bifunctional cross-linkers. Probably it is also expressed on the cell membrane as a tetramer. Crosslinking or activation may thus bring about a tetrameric assembly of gC1q-R followed by a conformational change within the molecule, thereby exposing epitopes which are otherwise hidden. A form of GC1q-R is also found inside the cell. Intracellular gC1q-R has been shown to bind the cytoplasmic tail of the a1B-adrenergic receptor and to PKCµ. The monoclonal antibody 60.11 is directed against epitopes situated within the NH2-terminal stretch of gC1q-R corresponding to residues 76-93. Clone 60.11 recognizes the putative C1q binding site and reacts with the mature form, but has poor or no reactivity with the truncated form, lacking residues 74-95.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NBP1-80963
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-33736
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-49833
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, PEP-ELISA
NBP2-31844
Species: Hu
Applications: ICC/IF, IHC, IHC-P
H00001032-M08
Species: Hu
Applications: WB, ELISA, IP
NB200-106
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-33581
Species: Hu, Rt
Applications: ICC/IF, IHC, IHC-P
AF4937
Species: Hu
Applications: WB, IHC
MAB25301
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
NBP1-97491
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, GP, Ha, Mk, Rb, Sh
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NB100-615
Species: Hu, Mu, Rt, Sh
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NBP1-31116
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
NBP1-47974
Species: Hu, Rt, Ca, Pm
Applications: WB, ICC/IF, IHC, IHC-P
AF3014
Species: Hu
Applications: WB, IHC, Block
NB300-223
Species: Hu, Mu, Rt, Ca
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-87402
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-87679
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P

Publications for PLVAP Antibody (NBP1-51694) (0)

There are no publications for PLVAP Antibody (NBP1-51694).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for PLVAP Antibody (NBP1-51694) (0)

There are no reviews for PLVAP Antibody (NBP1-51694). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for PLVAP Antibody (NBP1-51694) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional PLVAP Products

Bioinformatics Tool for PLVAP Antibody (NBP1-51694)

Discover related pathways, diseases and genes to PLVAP Antibody (NBP1-51694). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for PLVAP Antibody (NBP1-51694)

Discover more about diseases related to PLVAP Antibody (NBP1-51694).
 

Pathways for PLVAP Antibody (NBP1-51694)

View related products by pathway.

PTMs for PLVAP Antibody (NBP1-51694)

Learn more about PTMs related to PLVAP Antibody (NBP1-51694).

Blogs on PLVAP

There are no specific blogs for PLVAP, but you can read our latest blog posts.

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our PLVAP Antibody (174/2) and receive a gift card or discount.

Bioinformatics

Gene Symbol PLVAP
Entrez