PLD1 Antibody

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Immunohistochemistry-Paraffin: PLD1 Antibody [NBP1-19425] - Human heart tissue.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-19425
    • Availability
      Product Discontinued

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PLD1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 524-573 of Human PC-PLD1.
Clonality
Polyclonal
Host
Rabbit
Gene
PLD1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Immunohistochemistry (IHC) analyzes of PLD1 (K556) pAb in paraffin-embedded human heart tissue.

Reactivity Notes

Cross reacts with Human, Mouse and Rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PLD1 Antibody

  • Choline phosphatase 1
  • EC 3.1.4.4
  • hPLD1
  • Phosphatidylcholine-hydrolyzing phospholipase D1
  • phospholipase D1
  • phospholipase D1, phophatidylcholine-specific
  • phospholipase D1, phosphatidylcholine-specific
  • PLD 1
  • PLD1

Background

Activation of phosphatidylcholine-specific phospholipase D (PC-PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA). Insulin activates the PLD-dependent hydrolysis of PC in plasma membranes of adipocytes by a mechanism that may involve wortmannin-sensitive phosphatidylinositol 3-kinase. In addition to the transient activation by growth factors stimulation, PC-PLD is constitutively activated in some of the Src- and Ras-transformed cells. PC-PLD is one of the target enzymes of ischemia; its decrease may cause a perturbation of PC hydrolysis and/or disorders of intracellular signal transduction or choline metabolism for acetylcholine formation in the brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PLD1
Entrez