PLC-gamma 1 Antibody


Western Blot: PLC-gamma 1 Antibody [NB100-91932] - Western blot (WB) analysis of Phospholipase C gamma 1 (G777) antibody in extracts from 293 cells treated with EGF 200ng/ml, 30mins.
Immunohistochemistry-Paraffin: PLC-gamma 1 Antibody [NB100-91932] - Phospholipase C gamma 1 Antibody [NB100-91932] - Paraffin-embedded human breast carcinoma tissue.
Immunohistochemistry: PLC-gamma 1 Antibody [NB100-91932] - Phospholipase C gamma 1 Antibody [NB100-91932] - Paraffin-embedded human breast carcinoma tissue

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PLC-gamma 1 Antibody Summary

Synthetic peptide, corresponding to amino acids 740-790 of Human PLC gamma1.
Immunogen affinity purified
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  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Phospholipase C gamma 1 (G777) pAb in extracts from 293 cells treated with EGF 200ng/ml, 30mins.
Immunohistochemistry (IHC) analyzes of Phospholipase C gamma 1 (G777) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
155 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
PLC-gamma 1 Lysate (NBP2-66254)

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.05% Sodium Azide
1.0 mg/ml
Immunogen affinity purified

Alternate Names for PLC-gamma 1 Antibody

  • EC
  • gamma 1 (formerly subtype 148)
  • monophosphatidylinositol phosphodiesterase
  • NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
  • phosphatidylinositol phospholipase C
  • phosphoinositidase C
  • phosphoinositide phospholipase C
  • Phosphoinositide phospholipase C-gamma-1
  • phospholipase C, gamma 1
  • phospholipase C-148
  • Phospholipase C-gamma-1
  • Phospholipase C-II
  • PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
  • PLC148
  • PLC-148
  • PLCG1
  • PLCgamma 1
  • PLC-gamma 1
  • PLC-gamma-1
  • PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
  • triphosphoinositide phosphodiesterase


Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, Phospholipase C gamma 1, PLC gamma2, PLC delta1, PLC delta2 and PLC episilon. PLC gamma1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC gamma1 in the brush border of intestinal epithelial cells. Villin regulates PLC gamma1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC gamma1 binds alpha1beta1 Integrin and modulates alpha1beta1 Integrin-specific adhesion. Phospholipase C gamma 1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells. Phospholipase C gamma 1 is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation, and may have a protective function during cellular response to oxidative stress.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

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Gene Symbol PLCG1