PLC-gamma 1 Antibody

Images

 
Western Blot: PLC-gamma 1 Antibody [NB100-91932] - Western blot (WB) analysis of Phospholipase C gamma 1 (G777) antibody in extracts from 293 cells treated with EGF 200ng/ml, 30mins.
Immunohistochemistry-Paraffin: PLC-gamma 1 Antibody [NB100-91932] - Phospholipase C gamma 1 Antibody [NB100-91932] - Paraffin-embedded human breast carcinoma tissue.
Immunohistochemistry: PLC-gamma 1 Antibody [NB100-91932] - Phospholipase C gamma 1 Antibody [NB100-91932] - Paraffin-embedded human breast carcinoma tissue

Product Details

Summary
Product Discontinued
View other related PLC-gamma 1 Primary Antibodies

Order Details


    • Catalog Number
      NB100-91932
    • Availability
      Product Discontinued

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PLC-gamma 1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 740-790 of Human PLC gamma1.
Clonality
Polyclonal
Host
Rabbit
Gene
PLCG1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of Phospholipase C gamma 1 (G777) pAb in extracts from 293 cells treated with EGF 200ng/ml, 30mins.
Immunohistochemistry (IHC) analyzes of Phospholipase C gamma 1 (G777) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
155 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PLC-gamma 1 Antibody

  • EC 3.1.4.11
  • gamma 1 (formerly subtype 148)
  • monophosphatidylinositol phosphodiesterase
  • NCKAP3,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
  • phosphatidylinositol phospholipase C
  • phosphoinositidase C
  • phosphoinositide phospholipase C
  • Phosphoinositide phospholipase C-gamma-1
  • phospholipase C, gamma 1
  • phospholipase C-148
  • Phospholipase C-gamma-1
  • Phospholipase C-II
  • PLC11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1
  • PLC148
  • PLC-148
  • PLCG1
  • PLCgamma 1
  • PLC-gamma 1
  • PLC-gamma-1
  • PLC-II1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
  • PPLCA
  • triphosphoinositide phosphodiesterase

Background

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, Phospholipase C gamma 1, PLC gamma2, PLC delta1, PLC delta2 and PLC episilon. PLC gamma1 is widely distributed in bronchiolar epithelium, type I and II pneumocytes and fibroblasts of the interstitial tissue. Actinregulatory protein Villin is tyrosine phosphorylated and associates with PLC gamma1 in the brush border of intestinal epithelial cells. Villin regulates PLC gamma1 activity by modifying its own ability to bind phosphatidylinositol 4,5-biphosphate. PLC gamma1 binds alpha1beta1 Integrin and modulates alpha1beta1 Integrin-specific adhesion. Phospholipase C gamma 1 and Ca2+ play a direct role in VEGF-regulated endothelial growth, however this signaling pathway is not linked to FGF-mediated effects in primary endothelial cells. Phospholipase C gamma 1 is rapidly activated in response to growth factor stimulation and plays an important role in regulating cell proliferation and differentiation, and may have a protective function during cellular response to oxidative stress.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PLCG1
Entrez