PKHD1 Antibody [DyLight 488]

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Product Details

Summary
Product Discontinued
View other related PKHD1 Primary Antibodies

Order Details


    • Catalog Number
      BC110-60478G
    • Availability
      Product Discontinued

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PKHD1 Antibody [DyLight 488] Summary

Immunogen
A synthetic peptide derived from the human PKHD1 protein (within residues 450-550). [UniProt# Q8TCZ9]
Localization
Membrane; single-pass type I membrane.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PKHD1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA 1:100-1:2000
Application Notes
This PKHD1 antibody is useful for peptide ELISA.

Reactivity Notes

Human. Immunogen sequence has 88% identity to mouse.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details. Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PKHD1 Antibody [DyLight 488]

  • polycystic kidney and hepatic disease 1 (autosomal recessive)

Background

PKHD1 is a type I membrane protein that undergoes regulated proteolysis. Many proteolytic cleavages occur on the ectodomain whereas at least one cleavage occurs on the cytoplasmic portion of PKHD1. The later generates a C-terminal intracellular fragment that localizes to the nucleus. This proteolysis requires activation of protein kinase C (PKC) and release of intracellular calcium. PKHD1 is expressed in the cilia of the bile duct epithelium and leads to abnormalities in the rubric of the ductal plate malformation. The intracellular C-terminus of PKHD1 interacts with calcium modulating cyclophilin ligand (CAML), a protein implicated in calcium signaling. PKHD1 may participate in the mediation of intracellular calcium in the distal nephron in a manner similar to PKD1 and PKD2. Mutations in the PKHD1 gene result in autosomal recessive polycystic kidney disease (ARPKD), a severe form of polycystic kidney disease characterized by enlarged kidneys and congenital hepatic fibrosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PKHD1