PI 3-Kinase p85 beta Antibody

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Tissue Culture Substratum: PI 3 Kinase p85 beta Antibody [NBP1-41067] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PIK3R2 antibody used for IP at 10 ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-41067
    • Availability
      Product Discontinued

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PI 3-Kinase p85 beta Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 125 and 175 of human phosphoinositide-3-kinase, regulatory subunit 2 using the numbering given in entry NP_005018.1 (GeneID 5296).
Clonality
Polyclonal
Host
Rabbit
Gene
PIK3R2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 5-15 ug/mg lysate
  • Tissue Culture Substratum

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PI 3-Kinase p85 beta Antibody

  • P85B
  • p85-beta
  • phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
  • phosphatidylinositol 3-kinase regulatory subunit beta
  • phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)
  • phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
  • PI 3Kinase p85 beta
  • PI 3-Kinase p85 beta
  • PI3K regulatory subunit beta
  • PI3-kinase regulatory subunit beta
  • PI3-kinase subunit p85-beta
  • PIK3R2
  • ptdIns-3-kinase regulatory subunit beta
  • ptdIns-3-kinase regulatory subunit p85-beta

Background

The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 beta). p85 beta is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 beta is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol PIK3R2
Entrez