Phospho-SHP-2 (Y542) DuoSet IC ELISA, 2 Plate

Images

 
A lysate from Jurkat human acute T cell leukemia cells was immunoprecipitated with the Phospho-SHP-2 (Y542) Capture Antibody. Unbound material was removed by washing. The bound material was solubilized in SDS-PAGE ...read more
NIH-3T3 mouse embryonic fibroblast cells were treated with 50 ng/mL of recombinant human PDGF-BB (Catalog # 220-BB) for 20 minutes. The lysates were either quantified with this DuoSet® IC ELISA or immunoblotted ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      DYC3790-2
    • Availability
      Product Discontinued

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Phospho-SHP-2 (Y542) DuoSet IC ELISA, 2 Plate Summary

Modification
p Tyr542
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
PTPN11

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DYC3790-2.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Phospho-SHP-2 (Y542) DuoSet IC ELISA, 2 Plate

  • BPTP3
  • EC 3.1.3.48
  • MGC14433
  • protein tyrosine phosphatase, non-receptor type 11
  • protein tyrosine phosphatase-2
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP1D
  • PTP-1D
  • PTP2C
  • PTP-2C
  • PTP2CNS1
  • PTPN11
  • SHP2
  • SHP-2
  • SHP2CFC
  • SHPTP2
  • SH-PTP2
  • SH-PTP2Noonan syndrome 1
  • SH-PTP3
  • tyrosine-protein phosphatase non-receptor type 11

Background

The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.

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Publications for SHP-2/PTPN11 (DYC3790-2)(5)

We have publications tested in 2 confirmed species: Human, Rat.


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Human
(4)
Rat
(1)
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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for SHP-2/PTPN11 (DYC3790-2). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

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Bioinformatics

Gene Symbol PTPN11