PHLPP Antibody


Western Blot: PHLPP Antibody [NB100-1811] - Detection of Human and Mouse PHLPP on HeLa whole cell lysate using NB100-1811. PHLPP was also immunoprecipitated using rabbit anti-PHLPP antibody NB100-1810.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB, IP
0.2 mg/ml

Order Details

PHLPP Antibody Summary

The immunogen recognized by this antibody maps to a region between residue 1150 and the C-terminus (residue 1205) of human PH Domain and Leucine Rich Repeat Protein Phosphatase using the numbering given in entry NP_919431.1 (GeneID 23239).
PHLPP antibody has been reported to cross reacts with beta-catenin, which may display 90kDa band. We would not recommend using this specific antibody for assays where signals may not be notable between PHLPP1 and Beta-Catenin.
Predicted Species
Primate (100%), Rhesus Macaque (100%)
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C. Do not freeze.
Tris-buffered Saline and 0.1% BSA
0.09% Sodium Azide
0.2 mg/ml
Immunogen affinity purified


  • Western Blot 1:2000-1:10000
  • Immunoprecipitation 1-4 ug/mg of lysate
Application Notes
Western Blot: Beta catenin band in Western blot is relatively less intense than PHLPP band. We do not recommend this antibody in Immunohistochemistry, Immunocytochemistry and Immunofluorescence due to its cross reactivity to Beta Catenin. Use in Immunocytochemistry/immunofluorescence and Immunohistochemistry-Paraffin reported in scientific literature (PMID 25820252)

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
185 kDa
Read Publications using
NB100-1811 in the following applications:

  • 1 publication
  • 1 publication
  • IP
    1 publication
  • WB
    1 publication

Reactivity Notes

Based on sequence homology, this antibody may react with Orangutan, Gorilla, Chimpanzee, Tasmanian devil, White-tufted-ear marmoset, Crab-eating macaque, Naked mole rat, Gray short-tailed opossum and Northern white-cheeked gibbon.

Alternate Names for PHLPP Antibody

  • EC
  • hSCOP
  • KIAA0606
  • MGC161555
  • PH domain and leucine rich repeat protein phosphatase 1
  • PH domain and leucine rich repeat protein phosphatase
  • PH domain leucine-rich repeat-containing protein phosphatase 1
  • pleckstrin homology domain containing, family E (with leucine rich repeats)member 1
  • Pleckstrin homology domain-containing family E member 1
  • SCN circadian oscillatory protein
  • SCOPPH domain-containing family E member 1
  • Suprachiasmatic nucleus circadian oscillatory protein


PHLPP (PH domain leucine-rich repeat-containing protein phosphatase) is responsible for the dephosphorylation and subsequent inactivation of Akt. Akt is a signaling protein critical to the balance of cell survival and apoptosis. Dephosphorylation of Akt by PHLPP has been demonstrated to trigger apoptosis and suppress tumor cell growth. PHLPP functions similarly to its relative PHLPPL, also known as PHLPPL2. Recent studies show that PHLPP and PHLPPL selectively terminate Akt-signaling by targeting specific Akt isoforms. Alternate names for PHLPP include pleckstrin homology domain-containing family E protein 1, suprachiasmatic nucleus circadian oscillatory protein, hSCOP, PHLPP1, KIAA0606, PLEKHE1, and SCOP.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC, ICFlow
Species: Hu, Mu, Rt
Applications: WB, IP
Species: Hu, Mu, Rt, Fe, GP, Rb
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP, GS
Species: Hu, Mu
Applications: WB, Simple Western
Species: Hu
Applications: WB, Flow, IHC, IHC-P
Species: Hu
Applications: IHC
Species: Hu
Applications: WB, IHC
Species: Hu
Applications: IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Species: Hu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IHC, ICFlow
Species: Hu, Rt, Ca, Mk
Applications: WB, IHC, IHC-P, IP
Species: Hu, Mu
Applications: WB, ICC/IF
Species: Hu, Mu, Rt, Ba, Bv, Ch
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC

Publications for PHLPP Antibody (NB100-1811)(5)

Reviews for PHLPP Antibody (NB100-1811) (0)

There are no reviews for PHLPP Antibody (NB100-1811). By submitting a review earn points towards our Rewards Program.
  • 250 points for product review
  • 500 additional points for an image with your product review
  • Double points (500) if you are the first to review this product
  • Double points (1000) if you are the first to review this product with an image

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for PHLPP Antibody (NB100-1811) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Additional PHLPP Antibody Products

Related Products by Gene

Bioinformatics Tool for PHLPP Antibody (NB100-1811)

Discover related pathways, diseases and genes to PHLPP Antibody (NB100-1811). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for PHLPP Antibody (NB100-1811)

Discover more about diseases related to PHLPP Antibody (NB100-1811).

Pathways for PHLPP Antibody (NB100-1811)

View related products by pathway.

PTMs for PHLPP Antibody (NB100-1811)

Learn more about PTMs related to PHLPP Antibody (NB100-1811).

Blogs on PHLPP

There are no specific blogs for PHLPP, but you can read our latest blog posts.

Contact Information

Product PDFs


Gene Symbol PHLPP1

Customer Resources

Novus Review - Submit your review and earn rewards points which can be used for merchandise & discounts.
Risk Free Testing - Test on a species/application not listed above to receive a full credit towards a future purchase.

Novus' Quality Guarantee - Novus guarantees that every product we sell will work in the application and species listed on our website and datasheets.

Submit your question on NB100-1811 below.
During business hours, we will respond to your email within 24 hours. For any questions submitted on the weekend, a response will be received on Monday.
For immediate assistance during business hours M- F (excluding major holidays), please contact us.
Ask a Scientist - We have a lab full of white coats just waiting for your scientific questions and concerns.

Customers Who Bought This Also Bought