PDGF R alpha Antibody (MM0004-8A89)

Images

 
Immunohistochemistry-Paraffin: PDGF Receptor alpha Antibody (MM0004-8A89) [NB110-60969] - Formalin fixed and paraffin embedded normal human placenta tissue is subjected to mouse anti human PDGFR alpha
Immunohistochemistry-Paraffin: PDGF Receptor alpha Antibody (MM0004-8A89) [NB110-60969] - Formalin fixed and paraffin embedded normal human placenta tissue is subjected to mouse anti human PDGFR-a.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clone
MM0004-8A89
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

PDGF R alpha Antibody (MM0004-8A89) Summary

Immunogen
N-terminal recombinant human platelet derived growth factor receptor alpha fragment.
Specificity
PDGF Receptor alpha. No cross-reactivity is shown with hPDGF Receptor beta.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
PDGFRA
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:100-400
  • Immunohistochemistry-Paraffin 1:100-1:400

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein G purified
Reconstitution Instructions
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for PDGF R alpha Antibody (MM0004-8A89)

  • alpha-type platelet-derived growth factor receptor
  • CD140 antigen-like family member A
  • CD140a antigen
  • CD140a
  • EC 2.7.10
  • EC 2.7.10.1
  • MGC74795
  • PDGF R alpha
  • PDGFR alpha
  • PDGFR2
  • PDGFRA
  • PDGFRA/BCR fusion
  • PDGF-R-alpha
  • platelet-derived growth factor receptor, alpha polypeptide
  • rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein
  • RHEPDGFRA

Background

Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Bioinformatics

Gene Symbol PDGFRA
Entrez
Uniprot