Recombinant Human PDGF-B Protein Summary
A partial recombinant protein with a His tag corresponding to amino acids Ser67 - Thr175 of PDGFB.
| Protein/Peptide Type
Partial Recombinant Protein
Less than 0.01 ng/ug cytokine as determined by the LAL assay.
The ED50 of this protein, as measured by Balb/c-3T3 proliferation, is less
than or equal to 30 ng/mL. This corresponds to a specific activity of greater than or equal to 3.3 x 10e4 Units/mg
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
This protein was made to the human sequence.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Phosphate buffered saline, pH 7.2, 150 mM NaCl, with 1.0% BSA. 0.22 um filtered.For best recovery, quick-spin vial prior to opening. Use in a sterile environment
0.09% Sodium Azide
Alternate Names for Recombinant Human PDGF-B Protein
- B chain
- PDGF subunit B
- platelet-derived growth factor 2
- platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis)oncogene homolog)
- Platelet-derived growth factor beta polypeptide
- platelet-derived growth factor subunit B
- platelet-derived growth factor, B chain
- Platelet-derived growth factor, beta polypeptide (oncogene SIS)
- Proto-oncogene c-Sis
PDGF-BB is a member of the platelet-derived growth factor family, a group of proteins that are released by platelets upon activation. The PDGF proteins are dimers of two of four peptide chains designated A, B, C, and D. PDGF-BB is formed by two B-chains, while PDGF-AB is one B chain and one A-chain forming the only heterodimer in the family. PDGF-BB is unique among the family in that it can bind to and activate all three forms of the PDGF receptor. It induces the proliferation, migration, and survival of fibroblasts, endothelial cells, epithelial cells, and smooth muscle cells. PDGF-BB is important for angiogenesis and smooth muscle formation during embryonic development, and plays a role in wound healing and regeneration in adults. High levels of PDGF-BB are often detected in malignant tumors, and it is believed to facilitate tumor metastasis and vascularization.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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